RESVERATROL PROTECTS WHOLE BODY HEAT STRESS-INDUCED TESTICULAR DAMAGE IN RAT MODEL

Objective: The local thermoregulation in testis is important for optimum spermatozoa development. Excessive heat hampers this regulation resulting alteration of normal testicular function. present investigation confirms the role free radicals hyperthermia induced oxidative damage and elucidates dose-dependent ameliorating effect resveratrol (RSV) against damage. aim also to observe selective concentration RSV on changes damaged tissue. Methods: 48 male Wister rats were exposed hyperthermic condition past 7 days total 21 experiment. was pre- co-treated with stress daily a manner (1 mg, 5 10 mg/kg body weight) 21days. Results: Reactive oxygen species level estimated using flow cytometry. Enhancement hepatotoxicity markers serum, lipid peroxidation decreasing antioxidant status homogenate demonstrated that Conclusion: Histological study along biochemical molecular assessment redox balance tissue revealed significantly ameliorated testis. findings suggest an effective polyphenolic compound can protect